Assay Detail
Binding
CHEMBL5336813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant BACE1 using Rh-EVNLDAEFK-quencher as substrate incubated for 60 mins by FRET assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.26 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378225 | — | — | 1 | 7.23 |
| CHEMBL5423316 | — | — | 1 | 5.80 |
| CHEMBL4861574 | — | — | 1 | 5.39 |
| CHEMBL4852705 | — | — | 1 | 5.31 |
| CHEMBL5423337 | — | — | 1 | 5.29 |
| CHEMBL4859850 | — | — | 1 | 5.29 |
| CHEMBL5404846 | — | — | 1 | 5.27 |
| CHEMBL5411905 | — | — | 1 | 5.27 |
| CHEMBL4854550 | — | — | 1 | 5.17 |
| CHEMBL5440565 | — | — | 1 | 5.03 |
| CHEMBL4849009 | — | — | 1 | 4.76 |
| CHEMBL4868987 | — | — | 1 | 4.71 |
| CHEMBL5411369 | — | — | 1 | 4.64 |
| CHEMBL4873878 | — | — | 1 | 4.54 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | - |
| CHEMBL5411893 | — | — | 1 | - |
| CHEMBL5419680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378225 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5423316 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL4861574 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4852705 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL5423337 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL4859850 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL5404846 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL5411905 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL4854550 | — | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL5440565 | — | IC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL4849009 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4868987 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL5411369 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4873878 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - | |
| CHEMBL95 | TACRINE | IC50 | - | — | - | |
| CHEMBL1428 | NIMODIPINE | IC50 | - | — | - | |
| CHEMBL5411893 | — | IC50 | - | — | - | |
| CHEMBL5419680 | — | IC50 | - | — | - |