Assay Detail
Binding
CHEMBL5336847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse GAT1
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium- and chloride-dependent GABA transporter 1 (CHEMBL5445) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.54 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1190271 | — | — | 2 | 6.52 |
| CHEMBL2403791 | — | — | 1 | 5.05 |
| CHEMBL5431496 | — | — | 1 | 4.89 |
| CHEMBL5430628 | — | — | 1 | 4.72 |
| CHEMBL3403559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1190271 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1190271 | — | IC50 | = | 309.03 | nM | 6.51 |
| CHEMBL2403791 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5431496 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5430628 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3403559 | — | IC50 | = | 562341.33 | nM | - |