Assay Detail
Binding
CHEMBL5337119
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Binding affinity to 5-HT6 receptor (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT<sub>6</sub> Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.99 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083390 | INTEPIRDINE | 3.0 | 1 | 9.77 |
| CHEMBL362628 | — | — | 1 | 9.24 |
| CHEMBL1210710 | SB-399885 | — | 1 | 9.10 |
| CHEMBL431298 | — | — | 1 | 8.90 |
| CHEMBL5219240 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083390 | INTEPIRDINE | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL362628 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL1210710 | SB-399885 | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL431298 | — | Ki | = | 1.26 | nM | 8.90 |
| CHEMBL5219240 | — | Ki | = | 11.0 | nM | 7.96 |