Assay Detail
Functional
CHEMBL5337474
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 to 96 hrs by alamar blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of dihydropteridone derivatives as novel PLK1 and BRD4 dual inhibitor for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.57 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419367 | — | — | 1 | 8.04 |
| CHEMBL5401381 | — | — | 1 | 7.91 |
| CHEMBL5418129 | — | — | 1 | 7.86 |
| CHEMBL5395480 | — | — | 1 | 7.77 |
| CHEMBL5429440 | — | — | 1 | 7.76 |
| CHEMBL5417495 | — | — | 1 | 7.67 |
| CHEMBL5416208 | — | — | 1 | 7.64 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.54 |
| CHEMBL5421238 | — | — | 1 | 7.46 |
| CHEMBL5403358 | — | — | 1 | 7.24 |
| CHEMBL5428087 | — | — | 1 | 7.22 |
| CHEMBL5394764 | — | — | 1 | 7.21 |
| CHEMBL5415794 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419367 | — | IC50 | = | 9.22 | nM | 8.04 |
| CHEMBL5401381 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL5418129 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL5395480 | — | IC50 | = | 16.9 | nM | 7.77 |
| CHEMBL5429440 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL5417495 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL5416208 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL513909 | BI-2536 | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL5421238 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL5403358 | — | IC50 | = | 58.2 | nM | 7.24 |
| CHEMBL5428087 | — | IC50 | = | 60.4 | nM | 7.22 |
| CHEMBL5394764 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL5415794 | — | IC50 | = | 78.3 | nM | 7.11 |