Assay Detail
Binding
CHEMBL5337581
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Inhibition of recombinant Bfl-1 (1-152) (unknown origin) by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of (2-naphthylthio)acetic acid derivative as selective Bfl-1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.72 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | — | 1 | 6.75 |
| CHEMBL2030270 | — | — | 1 | 5.34 |
| CHEMBL1331211 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL2030270 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL1331211 | — | IC50 | = | 8410.0 | nM | 5.08 |