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Assay Detail

CHEMBL5337583

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Binding
Inhibition of Bfl-1 (unknown origin) assessed as inhibition constant
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bcl-2-related protein A1 (CHEMBL6044)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and optimization of (2-naphthylthio)acetic acid derivative as selective Bfl-1 inhibitor.
Niu P, Xu H, Fan M.
Bioorg Med Chem Lett (2024) 101 : 129658 -129658
PubMed 38373466 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.73 6.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5401950 1 6.20
CHEMBL5420281 1 6.12
CHEMBL3260038 1 5.96
CHEMBL5440532 1 5.85
CHEMBL5438295 1 5.79
CHEMBL5413651 1 5.74
CHEMBL5418778 1 5.72
CHEMBL5433077 1 5.71
CHEMBL3265294 1 5.66
CHEMBL3260039 1 5.52
CHEMBL1331211 1 5.50
CHEMBL3260035 1 5.49
CHEMBL5438598 1 5.21
CHEMBL5421542 1 -
CHEMBL5394425 1 -
CHEMBL5415310 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5401950 Ki = 630.0 nM 6.20
CHEMBL5420281 Ki = 750.0 nM 6.12
CHEMBL3260038 Ki = 1090.0 nM 5.96
CHEMBL5440532 Ki = 1410.0 nM 5.85
CHEMBL5438295 Ki = 1630.0 nM 5.79
CHEMBL5413651 Ki = 1840.0 nM 5.74
CHEMBL5418778 Ki = 1920.0 nM 5.72
CHEMBL5433077 Ki = 1970.0 nM 5.71
CHEMBL3265294 Ki = 2210.0 nM 5.66
CHEMBL3260039 Ki = 3010.0 nM 5.52
CHEMBL1331211 Ki = 3170.0 nM 5.50
CHEMBL3260035 Ki = 3230.0 nM 5.49
CHEMBL5438598 Ki = 6190.0 nM 5.21
CHEMBL5421542 Ki > 50000.0 nM -
CHEMBL5394425 Ki > 50000.0 nM -
CHEMBL5415310 Ki > 50000.0 nM -