Assay Detail
Functional
CHEMBL5337785
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biochemical and Structural Studies of the Carminomycin 4-<i>O</i>-Methyltransferase DnrK.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.11 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474260 | CARUBICIN | 2.0 | 1 | 7.88 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.70 |
| CHEMBL1096602 | ARANCIAMYCIN | — | 1 | 5.57 |
| CHEMBL5397617 | — | — | 1 | 5.55 |
| CHEMBL5428775 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474260 | CARUBICIN | IC50 | = | 13.09 | nM | 7.88 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL1096602 | ARANCIAMYCIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5397617 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5428775 | — | IC50 | = | 13800.0 | nM | 4.86 |