Assay Detail
Functional
CHEMBL5337786
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biochemical and Structural Studies of the Carminomycin 4-<i>O</i>-Methyltransferase DnrK.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.21 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474260 | CARUBICIN | 2.0 | 1 | 7.46 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.77 |
| CHEMBL1096602 | ARANCIAMYCIN | — | 1 | 5.96 |
| CHEMBL5397617 | — | — | 1 | 5.51 |
| CHEMBL5428775 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474260 | CARUBICIN | IC50 | = | 34.98 | nM | 7.46 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 170.1 | nM | 6.77 |
| CHEMBL1096602 | ARANCIAMYCIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5397617 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5428775 | — | IC50 | = | 4300.0 | nM | 5.37 |