Assay Detail
Functional
CHEMBL5337903
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Anticancer activity against human A549 cells measured after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of <i>Plasmodial</i> cysteine protease inhibitors for the treatment of malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.20 | 4.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5437766 | — | — | 1 | 4.33 |
| CHEMBL5394154 | — | — | 1 | 4.22 |
| CHEMBL5400091 | — | — | 1 | 4.21 |
| CHEMBL5434874 | — | — | 1 | 4.04 |
| CHEMBL5395561 | — | — | 1 | - |
| CHEMBL5398485 | — | — | 1 | - |
| CHEMBL5422873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5437766 | — | IC50 | = | 47100.0 | nM | 4.33 |
| CHEMBL5394154 | — | IC50 | = | 59520.0 | nM | 4.22 |
| CHEMBL5400091 | — | IC50 | = | 61390.0 | nM | 4.21 |
| CHEMBL5434874 | — | IC50 | = | 91790.0 | nM | 4.04 |
| CHEMBL5395561 | — | IC50 | = | 203400.0 | nM | - |
| CHEMBL5398485 | — | IC50 | = | 120500.0 | nM | - |
| CHEMBL5422873 | — | IC50 | = | 513500.0 | nM | - |