Assay Detail
Binding
CHEMBL5337965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of urease (unknown origin) using urea as substrate preincubated for 30 mins followed by substrate addition and measured after 20 mins by red phenol reagent based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
<i>In vitro</i> biological evaluation and <i>in silico</i> studies of linear diarylheptanoids from <i>Curcuma aromatica</i> Salisb. as urease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.60 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1824567 | — | — | 1 | 5.02 |
| CHEMBL464562 | — | — | 1 | 4.66 |
| CHEMBL467 | HYDROXYUREA | 4.0 | 1 | 4.11 |
| CHEMBL5401061 | — | — | 1 | - |
| CHEMBL5396837 | — | — | 1 | - |
| CHEMBL5429620 | — | — | 1 | - |
| CHEMBL1824568 | — | — | 1 | - |
| CHEMBL2426107 | — | — | 1 | - |
| CHEMBL2426108 | — | — | 1 | - |
| CHEMBL5422737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1824567 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL464562 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL467 | HYDROXYUREA | IC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL5401061 | — | IC50 | = | 129300.0 | nM | - |
| CHEMBL5396837 | — | IC50 | = | 223100.0 | nM | - |
| CHEMBL5429620 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL1824568 | — | IC50 | = | 152700.0 | nM | - |
| CHEMBL2426107 | — | IC50 | = | 228300.0 | nM | - |
| CHEMBL2426108 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL5422737 | — | IC50 | > | 250000.0 | nM | - |