Assay Detail
Functional
CHEMBL5338523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum NF54 infected in human erythrocytes measured after 48 hrs by [3H]hypoxanthine incorporation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
hERG, <i>Plasmodium</i> Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.18 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.40 |
| CHEMBL5273140 | — | — | 1 | 7.92 |
| CHEMBL5434807 | — | — | 1 | 7.77 |
| CHEMBL5434251 | — | — | 1 | 7.27 |
| CHEMBL5410878 | — | — | 1 | 6.95 |
| CHEMBL5422455 | — | — | 1 | 6.83 |
| CHEMBL5429029 | — | — | 1 | 6.66 |
| CHEMBL5403581 | — | — | 1 | 6.61 |
| CHEMBL5436114 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5273140 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5434807 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5434251 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5410878 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5422455 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5429029 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5403581 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL5436114 | — | IC50 | = | 644.0 | nM | 6.19 |