Assay Detail
Toxicity
CHEMBL5338527
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Inhibition of human ERG expressed in CHO K1 cells measured after 4 min by QPatch assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
hERG, <i>Plasmodium</i> Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.22 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 8.40 |
| CHEMBL5434251 | — | — | 1 | 6.38 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.25 |
| CHEMBL5273140 | — | — | 1 | 6.20 |
| CHEMBL5410878 | — | — | 1 | 6.08 |
| CHEMBL5429029 | — | — | 1 | 6.01 |
| CHEMBL5436114 | — | — | 1 | 5.78 |
| CHEMBL5403581 | — | — | 1 | 5.57 |
| CHEMBL5434807 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5434251 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5273140 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5410878 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5429029 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5436114 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5403581 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL5434807 | — | IC50 | = | 5070.0 | nM | 5.29 |