Assay Detail
Functional
CHEMBL5338531
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Antiplasmodial activity against liver stage sporozoite Plasmodium berghei infected in HepG2 cells measured after 48 hrs by flow cytometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
hERG, <i>Plasmodium</i> Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.72 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5273140 | — | — | 1 | 6.31 |
| CHEMBL5434807 | — | — | 1 | 5.64 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5273140 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5434807 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 6000.0 | nM | 5.22 |