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Assay Detail

CHEMBL5339020

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SGC-7901
Confidence 1 — Organism
Curated By Autocuration

Target

SGC-7901 (CHEMBL614909)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy.
Liang Z, Wang Y, Zhang H, Deng J, Lei F, Li J, Shi T, Wang S, Li R, Wang Z.
Eur J Med Chem (2022) 239 : 114530 -114530
PubMed 35728506 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.89 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5422374 1 6.89
CHEMBL5088783 1 6.62
CHEMBL5426201 1 6.57
CHEMBL5431322 1 6.55
CHEMBL5432481 1 6.24
CHEMBL5089162 1 6.16
CHEMBL5088009 1 6.07
CHEMBL5079227 1 6.07
CHEMBL5428292 1 6.06
CHEMBL5401775 1 6.05
CHEMBL5413206 1 6.05
CHEMBL5085481 1 5.87
CHEMBL5396395 1 5.81
CHEMBL5073538 1 5.78
CHEMBL5436992 1 5.73
CHEMBL5089958 1 5.73
CHEMBL5069960 1 5.71
CHEMBL5083769 1 5.70
CHEMBL5397925 1 5.66
CHEMBL5431925 1 5.63
CHEMBL81925 1 5.44
CHEMBL5075370 1 5.44
CHEMBL5072392 1 5.41
CHEMBL84 TOPOTECAN 4.0 1 5.38
CHEMBL5084381 1 5.25
CHEMBL5420197 1 5.18
CHEMBL5079362 1 -
CHEMBL5428490 1 -
CHEMBL5082035 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5422374 IC50 = 130.0 nM 6.89
CHEMBL5088783 IC50 = 240.0 nM 6.62
CHEMBL5426201 IC50 = 270.0 nM 6.57
CHEMBL5431322 IC50 = 280.0 nM 6.55
CHEMBL5432481 IC50 = 570.0 nM 6.24
CHEMBL5089162 IC50 = 690.0 nM 6.16
CHEMBL5088009 IC50 = 860.0 nM 6.07
CHEMBL5079227 IC50 = 850.0 nM 6.07
CHEMBL5428292 IC50 = 880.0 nM 6.06
CHEMBL5401775 IC50 = 890.0 nM 6.05
CHEMBL5413206 IC50 = 890.0 nM 6.05
CHEMBL5085481 IC50 = 1360.0 nM 5.87
CHEMBL5396395 IC50 = 1550.0 nM 5.81
CHEMBL5073538 IC50 = 1670.0 nM 5.78
CHEMBL5436992 IC50 = 1860.0 nM 5.73
CHEMBL5089958 IC50 = 1860.0 nM 5.73
CHEMBL5069960 IC50 = 1940.0 nM 5.71
CHEMBL5083769 IC50 = 2010.0 nM 5.70
CHEMBL5397925 IC50 = 2210.0 nM 5.66
CHEMBL5431925 IC50 = 2360.0 nM 5.63
CHEMBL81925 IC50 = 3600.0 nM 5.44
CHEMBL5075370 IC50 = 3610.0 nM 5.44
CHEMBL5072392 IC50 = 3860.0 nM 5.41
CHEMBL84 TOPOTECAN IC50 = 4170.0 nM 5.38
CHEMBL5084381 IC50 = 5600.0 nM 5.25
CHEMBL5420197 IC50 = 6620.0 nM 5.18
CHEMBL5079362 IC50 > 18000.0 nM -
CHEMBL5428490 IC50 = 132000.0 nM -
CHEMBL5082035 IC50 > 18000.0 nM -