Assay Detail
Binding
CHEMBL5339141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LSD1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.73 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5433883 | — | — | 1 | 9.00 |
| CHEMBL5439167 | — | — | 1 | 8.85 |
| CHEMBL5286191 | — | — | 1 | 8.54 |
| CHEMBL3775474 | — | — | 1 | 8.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5433883 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5439167 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5286191 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3775474 | — | IC50 | = | 2.9 | nM | 8.54 |