Assay Detail
Functional
CHEMBL5339377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human LoVo cells assessed as cell growth inhibition by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.83 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587222 | — | — | 1 | 6.03 |
| CHEMBL5406658 | — | — | 1 | 5.89 |
| CHEMBL5409449 | — | — | 1 | 5.80 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.58 |
| CHEMBL4303214 | FRUQUINTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587222 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5406658 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5409449 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4303214 | FRUQUINTINIB | IC50 | > | 10000.0 | nM | - |