Assay Detail
Functional
CHEMBL5339380
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Anticancer activity against human MKN-45 cells assessed as cell growth inhibition by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of (S)-1-(2-(2,4-difluorophenyl)-4-oxothiazolidin-3-yl)-3-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)urea as a potential anti-colorectal cancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.28 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 6.85 |
| CHEMBL5409449 | — | — | 1 | 6.42 |
| CHEMBL4587222 | — | — | 1 | 6.21 |
| CHEMBL5406658 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5409449 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4587222 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5406658 | — | IC50 | = | 2300.0 | nM | 5.64 |