Assay Detail
Functional
CHEMBL5339840
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Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caov-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.66 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082807 | — | — | 1 | 7.10 |
| CHEMBL5402970 | — | — | 1 | 6.74 |
| CHEMBL5075067 | — | — | 1 | 6.62 |
| CHEMBL5410561 | — | — | 1 | 6.61 |
| CHEMBL5417468 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082807 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5402970 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL5075067 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL5410561 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL5417468 | — | IC50 | = | 558.0 | nM | 6.25 |