Assay Detail
Functional
CHEMBL5339853
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Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caov-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.70 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5418009 | — | — | 1 | 6.99 |
| CHEMBL5423125 | — | — | 1 | 6.96 |
| CHEMBL5411328 | — | — | 1 | 6.60 |
| CHEMBL5398269 | — | — | 1 | 6.60 |
| CHEMBL5415737 | — | — | 1 | 6.60 |
| CHEMBL5405801 | — | — | 1 | 6.60 |
| CHEMBL5405396 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5418009 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5423125 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5411328 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5398269 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5415737 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5405801 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5405396 | — | IC50 | = | 305.0 | nM | 6.52 |