Assay Detail
Binding
CHEMBL5339905
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length MLKL (unknown origin) expressed in human HEK293 cells assessed as dissociation constant incubated for 30 mins by Competition Binding Assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mixed lineage kinase domain-like protein (CHEMBL1938217) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 6.28 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188381 | GW806742X | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188381 | GW806742X | Kd | = | 530.0 | nM | 6.28 |