Assay Detail
Binding
CHEMBL5339944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant mouse MLKL pseudokinase domain (179 to 464 residues) expressed in Sf21 insect cells assessed as dissociation constant by Surface plasmon resonance assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mixed lineage kinase domain-like protein (CHEMBL5465354) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 5.03 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188381 | GW806742X | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188381 | GW806742X | Kd | = | 9300.0 | nM | 5.03 |