Assay Detail
Binding
CHEMBL5340252
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Inhibition of ERK5 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.08 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541479 | — | — | 1 | 8.10 |
| CHEMBL1944698 | ZOTIRACICLIB | 2.0 | 1 | 7.37 |
| CHEMBL2381342 | — | — | 1 | 7.23 |
| CHEMBL5421663 | — | — | 1 | 7.06 |
| CHEMBL1673046 | — | — | 1 | 6.62 |
| CHEMBL4303171 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541479 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1944698 | ZOTIRACICLIB | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2381342 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5421663 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1673046 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4303171 | — | IC50 | = | 810.0 | nM | 6.09 |