Assay Detail
Binding
CHEMBL5340260
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LSD1 (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lysine-Specific Demethylase 1 Promises to Be a Novel Target in Cancer Drug Resistance: Therapeutic Implications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.43 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4651180 | PULRODEMSTAT | 2.0 | 1 | 9.60 |
| CHEMBL4454677 | — | — | 1 | 8.85 |
| CHEMBL3104250 | — | — | 1 | 7.89 |
| CHEMBL5095243 | INCB-059872 | 1.0 | 1 | 7.75 |
| CHEMBL3786182 | GSK2879552 | 1.0 | 1 | 7.62 |
| CHEMBL4297641 | SECLIDEMSTAT | 2.0 | 1 | 6.90 |
| CHEMBL5272967 | — | — | 1 | 6.48 |
| CHEMBL4283683 | DOMATINOSTAT | 2.0 | 1 | 6.22 |
| CHEMBL1797639 | — | — | 1 | 5.60 |
| CHEMBL3906257 | — | — | 1 | - |
| CHEMBL4440976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4651180 | PULRODEMSTAT | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4454677 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3104250 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5095243 | INCB-059872 | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3786182 | GSK2879552 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4297641 | SECLIDEMSTAT | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5272967 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4283683 | DOMATINOSTAT | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1797639 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3906257 | — | IC50 | < | 20.0 | nM | - |
| CHEMBL4440976 | — | IC50 | < | 1000.0 | nM | - |