Assay Detail
Binding
CHEMBL5340493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21-CodonPlus competent cells using methyl glyoxylate as substrate incubated for 2 mins in presence of NADPH
24
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.50 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5418720 | — | — | 1 | 7.96 |
| CHEMBL5421140 | — | — | 1 | 7.89 |
| CHEMBL5431713 | — | — | 1 | 7.85 |
| CHEMBL5431549 | — | — | 2 | 7.82 |
| CHEMBL5400501 | — | — | 1 | 7.82 |
| CHEMBL5400147 | — | — | 1 | 7.80 |
| CHEMBL5414059 | — | — | 1 | 7.80 |
| CHEMBL5438141 | — | — | 1 | 7.80 |
| CHEMBL5414200 | — | — | 1 | 7.75 |
| CHEMBL5413369 | — | — | 1 | 7.72 |
| CHEMBL5399554 | — | — | 2 | 7.66 |
| CHEMBL5417323 | — | — | 1 | 7.66 |
| CHEMBL5397238 | — | — | 2 | 7.50 |
| CHEMBL5396251 | — | — | 2 | 7.36 |
| CHEMBL269455 | IMIRESTAT | 2.0 | 1 | 7.34 |
| CHEMBL5400944 | — | — | 1 | 7.28 |
| CHEMBL5397588 | — | — | 1 | 7.28 |
| CHEMBL5420064 | — | — | 1 | 7.25 |
| CHEMBL5423635 | — | — | 1 | 6.67 |
| CHEMBL5483061 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5418720 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5421140 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5431713 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5431549 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5400501 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5414059 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5400147 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5438141 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5414200 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5413369 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5417323 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5399554 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5399554 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5431549 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5397238 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5397238 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5396251 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL269455 | IMIRESTAT | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5400944 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5397588 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5396251 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5420064 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5423635 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL5483061 | — | IC50 | = | 903.0 | nM | 6.04 |