Assay Detail
Binding
CHEMBL5340494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldehyde as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL2246) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.74 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269455 | IMIRESTAT | 2.0 | 1 | 7.35 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.19 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 6.49 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269455 | IMIRESTAT | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL266497 | SORBINIL | IC50 | = | 1200.0 | nM | 5.92 |