Assay Detail
Binding
CHEMBL5340495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 6His-tagged human recombinant SCoR2 AKR1A1 expressed in Escherichia coli BL21-CodonPlus competent cells using SNO-CoA as substrate incubated for 2 mins in presence of NADPH
24
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL2246) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.21 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397238 | — | — | 2 | 7.60 |
| CHEMBL5431713 | — | — | 1 | 7.54 |
| CHEMBL5396251 | — | — | 2 | 7.48 |
| CHEMBL5400944 | — | — | 1 | 7.38 |
| CHEMBL5417323 | — | — | 1 | 7.29 |
| CHEMBL5438141 | — | — | 1 | 7.28 |
| CHEMBL269455 | IMIRESTAT | 2.0 | 1 | 7.24 |
| CHEMBL5431549 | — | — | 2 | 7.24 |
| CHEMBL5414200 | — | — | 1 | 7.23 |
| CHEMBL5399554 | — | — | 2 | 7.20 |
| CHEMBL5418720 | — | — | 1 | 7.18 |
| CHEMBL5400147 | — | — | 1 | 7.17 |
| CHEMBL5414059 | — | — | 1 | 7.17 |
| CHEMBL5400501 | — | — | 1 | 7.14 |
| CHEMBL5421140 | — | — | 1 | 7.13 |
| CHEMBL5413369 | — | — | 1 | 7.10 |
| CHEMBL5397588 | — | — | 1 | 7.09 |
| CHEMBL5483061 | — | — | 1 | 7.03 |
| CHEMBL5423635 | — | — | 1 | 6.91 |
| CHEMBL5420064 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397238 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5431713 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5396251 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5400944 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5397238 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5417323 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5438141 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5431549 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5431549 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL269455 | IMIRESTAT | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5414200 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5399554 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5418720 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5396251 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5400147 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5414059 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5400501 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5421140 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5413369 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5399554 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5397588 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5483061 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5423635 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5420064 | — | IC50 | = | 127.0 | nM | 6.90 |