Assay Detail
Binding
CHEMBL5340927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK2 (unknown origin) using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbamate JNK3 Inhibitors Show Promise as Effective Treatments for Alzheimer's Disease: In Vivo Studies on Mouse Models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.45 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5437462 | — | — | 1 | 6.90 |
| CHEMBL5396715 | — | — | 1 | 6.84 |
| CHEMBL5430912 | — | — | 1 | 6.82 |
| CHEMBL5418625 | — | — | 1 | 6.01 |
| CHEMBL5438365 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5437462 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL5396715 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL5430912 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5418625 | — | IC50 | = | 973.0 | nM | 6.01 |
| CHEMBL5438365 | — | IC50 | = | 2203.0 | nM | 5.66 |