Assay Detail
Functional
CHEMBL5341622
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Antiproliferative activity against parental human A2780S cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.33 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415595 | — | — | 1 | 8.80 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.57 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415595 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL107 | COLCHICINE | IC50 | = | 23.2 | nM | 7.63 |