Assay Detail
Functional
CHEMBL5341624
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Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415595 | — | — | 1 | 8.70 |
| CHEMBL5422119 | — | — | 1 | 7.75 |
| CHEMBL5417734 | — | — | 1 | 7.68 |
| CHEMBL4852240 | — | — | 1 | 7.54 |
| CHEMBL5394538 | — | — | 1 | 7.50 |
| CHEMBL5408636 | — | — | 1 | 7.48 |
| CHEMBL5431034 | — | — | 1 | 7.37 |
| CHEMBL5408121 | — | — | 1 | 7.22 |
| CHEMBL5429479 | — | — | 1 | 7.18 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.06 |
| CHEMBL4862445 | — | — | 1 | 7.01 |
| CHEMBL5415401 | — | — | 1 | 6.86 |
| CHEMBL5430075 | — | — | 1 | 6.71 |
| CHEMBL5436501 | — | — | 1 | 6.70 |
| CHEMBL5435747 | — | — | 1 | 6.62 |
| CHEMBL5397132 | — | — | 1 | 6.57 |
| CHEMBL5436288 | — | — | 1 | 6.51 |
| CHEMBL5412258 | — | — | 1 | 6.41 |
| CHEMBL5432944 | — | — | 1 | 6.31 |
| CHEMBL5403422 | — | — | 1 | 6.20 |
| CHEMBL5406755 | — | — | 1 | 6.17 |
| CHEMBL5428736 | — | — | 1 | 6.00 |
| CHEMBL5438931 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415595 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5422119 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5417734 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4852240 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5394538 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5408636 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5431034 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5408121 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5429479 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL107 | COLCHICINE | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4862445 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5415401 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL5430075 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL5436501 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL5435747 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL5397132 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL5436288 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5412258 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL5432944 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL5403422 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL5406755 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL5428736 | — | IC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL5438931 | — | IC50 | = | 5169.0 | nM | 5.29 |