Assay Detail
Functional
CHEMBL5341626
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.20 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415595 | — | — | 1 | 9.00 |
| CHEMBL5417734 | — | — | 1 | 8.22 |
| CHEMBL5422119 | — | — | 1 | 7.96 |
| CHEMBL4852240 | — | — | 1 | 7.82 |
| CHEMBL5431034 | — | — | 1 | 7.80 |
| CHEMBL5408636 | — | — | 1 | 7.75 |
| CHEMBL5394538 | — | — | 1 | 7.72 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.60 |
| CHEMBL5429479 | — | — | 1 | 7.52 |
| CHEMBL5408121 | — | — | 1 | 7.36 |
| CHEMBL4862445 | — | — | 1 | 7.31 |
| CHEMBL5430075 | — | — | 1 | 7.09 |
| CHEMBL5397132 | — | — | 1 | 7.06 |
| CHEMBL5406755 | — | — | 1 | 6.94 |
| CHEMBL5415401 | — | — | 1 | 6.92 |
| CHEMBL5435747 | — | — | 1 | 6.89 |
| CHEMBL5412258 | — | — | 1 | 6.68 |
| CHEMBL5436288 | — | — | 1 | 6.62 |
| CHEMBL5428736 | — | — | 1 | 6.61 |
| CHEMBL5436501 | — | — | 1 | 6.59 |
| CHEMBL5432944 | — | — | 1 | 6.45 |
| CHEMBL5403422 | — | — | 1 | 6.29 |
| CHEMBL5438931 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415595 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5417734 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5422119 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4852240 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5431034 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5408636 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5394538 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL107 | COLCHICINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5429479 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5408121 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4862445 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5430075 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5397132 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5406755 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5415401 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL5435747 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5412258 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5436288 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL5428736 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL5436501 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL5432944 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL5403422 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL5438931 | — | IC50 | = | 4701.0 | nM | 5.33 |