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Assay Detail

CHEMBL5342169

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human recombinant PSMA (unknown origin) assessed as inhibition constant incubated for 60 mins in presence of NAAG
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glutamate carboxypeptidase 2 (CHEMBL1892)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and Characterization of Squaramic Acid-Based Prostate-Specific Membrane Antigen Inhibitors for Prostate Cancer.
Wang X, Chen Y, Xiong Y, Zhang L, Wang B, Liu Y, Cui M.
J Med Chem (2023) 66 : 6889 -6904
PubMed 37161996 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 8.61 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL510924 1 10.30
CHEMBL5430537 1 9.40
CHEMBL5420828 1 9.39
CHEMBL5420877 1 9.07
CHEMBL5402167 1 9.05
CHEMBL5403987 1 8.97
CHEMBL5436898 1 8.87
CHEMBL5408845 1 8.60
CHEMBL5428246 1 7.47
CHEMBL5430047 1 6.97
CHEMBL5426725 1 6.66
CHEMBL5437912 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL510924 Ki = 0.05 nM 10.30
CHEMBL5430537 Ki = 0.4 nM 9.40
CHEMBL5420828 Ki = 0.41 nM 9.39
CHEMBL5420877 Ki = 0.86 nM 9.07
CHEMBL5402167 Ki = 0.9 nM 9.05
CHEMBL5403987 Ki = 1.07 nM 8.97
CHEMBL5436898 Ki = 1.35 nM 8.87
CHEMBL5408845 Ki = 2.49 nM 8.60
CHEMBL5428246 Ki = 33.82 nM 7.47
CHEMBL5430047 Ki = 107.0 nM 6.97
CHEMBL5426725 Ki = 221.0 nM 6.66
CHEMBL5437912 Ki - -