Assay Detail
Functional
CHEMBL5342675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human TMD8 cells incubated for 48 hrs by celltitre glo 2.0 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.92 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408743 | — | — | 1 | 8.85 |
| CHEMBL4754443 | — | — | 1 | 8.29 |
| CHEMBL4441907 | — | — | 1 | 7.92 |
| CHEMBL4065122 | FENEBRUTINIB | 3.0 | 1 | 7.90 |
| CHEMBL4450122 | — | — | 1 | 7.82 |
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408743 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4754443 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4441907 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4065122 | FENEBRUTINIB | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL4450122 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL43452 | POMALIDOMIDE | IC50 | = | 187.0 | nM | 6.73 |