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Assay Detail

CHEMBL5342767

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Binding
Inhibition of CK1epsilon (unknown origin)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Casein kinase I isoform epsilon (CHEMBL4937)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.
Choi JY, Noguchi Y, Alburger JM, Bayle S, Chung E, Grant W, Chaikuad A, Knapp S, Duckett DR, Roush WR.
J Med Chem (2023) 66 : 7162 -7178
PubMed 37204207 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 6.71 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1951415 1 8.10
CHEMBL2420704 1 7.55
CHEMBL5397065 1 7.52
CHEMBL2069623 1 7.50
CHEMBL5435232 1 7.48
CHEMBL5413697 1 7.44
CHEMBL5424568 1 7.24
CHEMBL569114 1 7.14
CHEMBL5419193 1 7.06
CHEMBL5435094 1 7.00
CHEMBL5428835 1 6.96
CHEMBL5414012 1 6.96
CHEMBL5398768 1 6.75
CHEMBL5409996 1 6.75
CHEMBL5415170 1 6.70
CHEMBL5440959 1 6.66
CHEMBL5434512 1 6.66
CHEMBL5413238 1 6.64
CHEMBL5438046 1 6.62
CHEMBL5431532 1 6.60
CHEMBL4211454 1 6.58
CHEMBL5407178 1 6.47
CHEMBL5434162 1 6.41
CHEMBL5402454 1 6.34
CHEMBL5395469 1 6.24
CHEMBL5426950 1 6.16
CHEMBL5406394 1 6.13
CHEMBL5438462 1 6.04
CHEMBL5396131 1 5.92
CHEMBL5431478 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1951415 IC50 = 8.0 nM 8.10
CHEMBL2420704 IC50 = 28.0 nM 7.55
CHEMBL5397065 IC50 = 30.0 nM 7.52
CHEMBL2069623 IC50 = 32.0 nM 7.50
CHEMBL5435232 IC50 = 33.0 nM 7.48
CHEMBL5413697 IC50 = 36.0 nM 7.44
CHEMBL5424568 IC50 = 58.0 nM 7.24
CHEMBL569114 IC50 = 73.0 nM 7.14
CHEMBL5419193 IC50 = 88.0 nM 7.06
CHEMBL5435094 IC50 = 100.0 nM 7.00
CHEMBL5428835 IC50 = 110.0 nM 6.96
CHEMBL5414012 IC50 = 110.0 nM 6.96
CHEMBL5398768 IC50 = 180.0 nM 6.75
CHEMBL5409996 IC50 = 180.0 nM 6.75
CHEMBL5415170 IC50 = 200.0 nM 6.70
CHEMBL5434512 IC50 = 220.0 nM 6.66
CHEMBL5440959 IC50 = 220.0 nM 6.66
CHEMBL5413238 IC50 = 230.0 nM 6.64
CHEMBL5438046 IC50 = 240.0 nM 6.62
CHEMBL5431532 IC50 = 250.0 nM 6.60
CHEMBL4211454 IC50 = 260.0 nM 6.58
CHEMBL5407178 IC50 = 340.0 nM 6.47
CHEMBL5434162 IC50 = 390.0 nM 6.41
CHEMBL5402454 IC50 = 460.0 nM 6.34
CHEMBL5395469 IC50 = 570.0 nM 6.24
CHEMBL5426950 IC50 = 690.0 nM 6.16
CHEMBL5406394 IC50 = 740.0 nM 6.13
CHEMBL5438462 IC50 = 910.0 nM 6.04
CHEMBL5396131 IC50 = 1200.0 nM 5.92
CHEMBL5431478 IC50 = 1400.0 nM 5.85
CHEMBL5401196 IC50 = 1800.0 nM 5.75
CHEMBL5436401 IC50 = 4600.0 nM 5.34