Assay Detail
Functional
CHEMBL5342863
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Antitumor activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.50 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410031 | — | — | 1 | 5.32 |
| CHEMBL5420913 | — | — | 1 | 4.93 |
| CHEMBL5417549 | — | — | 1 | 4.66 |
| CHEMBL5406988 | — | — | 1 | 4.54 |
| CHEMBL5399928 | — | — | 1 | 4.20 |
| CHEMBL5411495 | — | — | 1 | 4.17 |
| CHEMBL5428364 | — | — | 1 | 4.15 |
| CHEMBL5393726 | — | — | 1 | 4.01 |
| CHEMBL5422656 | — | — | 1 | - |
| CHEMBL5420161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410031 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5420913 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL5417549 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL5406988 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL5399928 | — | IC50 | = | 63700.0 | nM | 4.20 |
| CHEMBL5411495 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL5428364 | — | IC50 | = | 70900.0 | nM | 4.15 |
| CHEMBL5393726 | — | IC50 | = | 96500.0 | nM | 4.01 |
| CHEMBL5422656 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5420161 | — | IC50 | > | 100000.0 | nM | - |