Assay Detail
Binding
CHEMBL5342877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Skp2 in human MGC-803 cells treated with shRNA 5'-GGACCTATCGAACTCAGTTAT-3' incubated upto 48 hrs by Western blot analysis (Rvb = 7 +/- 1.1 microM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
S-phase kinase-associated protein 2 (CHEMBL3632458) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.41 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410031 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410031 | — | IC50 | = | 39200.0 | nM | 4.41 |