Assay Detail
Binding
CHEMBL5343261
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHP2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An Analysis of Successful Hit-to-Clinical Candidate Pairs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650521 | BATOPROTAFIB | 2.0 | 1 | 8.00 |
| CHEMBL4762625 | — | — | 1 | 7.52 |
| CHEMBL4445214 | — | — | 1 | 6.58 |
| CHEMBL4473316 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650521 | BATOPROTAFIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4762625 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4445214 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4473316 | — | IC50 | = | 12000.0 | nM | 4.92 |