Assay Detail
Binding
CHEMBL5343377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.87 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.52 |
| CHEMBL4442620 | RONICICLIB | 2.0 | 1 | 8.15 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.52 |
| CHEMBL4764656 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4442620 | RONICICLIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4764656 | — | IC50 | = | 50.0 | nM | 7.30 |