Assay Detail
Binding
CHEMBL5343629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at full length human Nurr1 transfected in HEK293T cells co-transfected with pFR-Luc-NRBE assessed as luciferase activity incubated for 16 hrs by dual-glo luciferase assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2 (CHEMBL5002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
<i>De Novo</i> Design of Nurr1 Agonists <i>via</i> Fragment-Augmented Generative Deep Learning in Low-Data Regime.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.56 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419377 | — | — | 1 | 7.40 |
| CHEMBL197194 | VIDOFLUDIMUS | 3.0 | 1 | 6.52 |
| CHEMBL5398399 | — | — | 1 | 5.77 |
| CHEMBL5428075 | — | — | 1 | - |
| CHEMBL5435108 | — | — | 1 | - |
| CHEMBL5395387 | — | — | 1 | - |
| CHEMBL5428771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419377 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL197194 | VIDOFLUDIMUS | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5398399 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5428075 | — | EC50 | - | — | - | |
| CHEMBL5435108 | — | EC50 | - | — | - | |
| CHEMBL5395387 | — | EC50 | - | — | - | |
| CHEMBL5428771 | — | EC50 | - | — | - |