Assay Detail
Binding
CHEMBL5343631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant N-terminal His6-tagged human Nurr1 LBD (362 to 598 residues) expressed in Escherichia coli BL21(DE3)-R3-pRARE2 by ITC method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2 (CHEMBL5002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
<i>De Novo</i> Design of Nurr1 Agonists <i>via</i> Fragment-Augmented Generative Deep Learning in Low-Data Regime.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.21 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419377 | — | — | 1 | 6.85 |
| CHEMBL197194 | VIDOFLUDIMUS | 3.0 | 1 | 6.16 |
| CHEMBL5398399 | — | — | 1 | 5.62 |
| CHEMBL5428075 | — | — | 1 | - |
| CHEMBL5435108 | — | — | 1 | - |
| CHEMBL5395387 | — | — | 1 | - |
| CHEMBL5428771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419377 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL197194 | VIDOFLUDIMUS | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL5398399 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL5428075 | — | Kd | - | — | - | |
| CHEMBL5435108 | — | Kd | - | — | - | |
| CHEMBL5395387 | — | Kd | - | — | - | |
| CHEMBL5428771 | — | Kd | - | — | - |