Assay Detail
Functional
CHEMBL5344102
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Agonist activity at N-terminal HA-tagged human GLP-1R expressed in HEK293 cells assessed as change in intracellular calcium level by Fluo-4 AM dye based calcium mobilization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.58 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410972 | — | — | 1 | 7.17 |
| CHEMBL5408881 | — | — | 1 | 6.78 |
| CHEMBL4518483 | DANUGLIPRON | 2.0 | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410972 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5408881 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL4518483 | DANUGLIPRON | EC50 | = | 1610.0 | nM | 5.79 |