Assay Detail
Binding
CHEMBL5344126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant BRD3 BD1 (unknown origin) assessed as dissociation constant measured for 1200 sec by bio-layer interferometry streptavidin sensor based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Precise Conformational Control Yielding Highly Potent and Exceptionally Selective BRD4 Degraders with Strong Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.34 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406183 | — | — | 1 | 7.85 |
| CHEMBL5409305 | — | — | 1 | 7.34 |
| CHEMBL4555209 | — | — | 1 | 7.14 |
| CHEMBL5421103 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406183 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL5409305 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL4555209 | — | Kd | = | 73.0 | nM | 7.14 |
| CHEMBL5421103 | — | Kd | = | 93.0 | nM | 7.03 |