Assay Detail
Binding
CHEMBL5344766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus system using FTS as substrate preincubated for 10 mins followed by substrate addition and measured after 2 hrs by fluorescence based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.38 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3655950 | — | — | 1 | 8.77 |
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 8.59 |
| CHEMBL356769 | TUBACIN | — | 1 | 8.40 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.33 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.82 |
| CHEMBL5075729 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3655950 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL356769 | TUBACIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5075729 | — | IC50 | = | 0.4 | nM | - |