Assay Detail
Binding
CHEMBL5344858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TRKC (unknown origin) using Kinase substrate 22 pre-incubated with compound for 10 mins followed by substrate and ATP addition measured after 30 mins by mobility shift assay based caliper reader analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.44 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3891994 | — | — | 1 | 6.16 |
| CHEMBL5424164 | — | — | 1 | 6.12 |
| CHEMBL5424443 | — | — | 1 | 5.61 |
| CHEMBL5408454 | — | — | 1 | 4.69 |
| CHEMBL5431604 | — | — | 1 | 4.60 |
| CHEMBL5429933 | — | — | 1 | - |
| CHEMBL5404930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3891994 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5424164 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5424443 | — | IC50 | = | 2483.7 | nM | 5.61 |
| CHEMBL5408454 | — | IC50 | = | 20211.0 | nM | 4.69 |
| CHEMBL5431604 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5429933 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL5404930 | — | IC50 | > | 500000.0 | nM | - |