Assay Detail
Binding
CHEMBL5344934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of GPX4 degradation in human NCI-H1650 cells incubated for 24 hrs by Western blot analysis
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H1650 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospholipid hydroperoxide glutathione peroxidase GPX4 (CHEMBL4295754) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual degradation mechanism of GPX4 degrader in induction of ferroptosis exerting anti-resistant tumor effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 1 | - | - |
| EC50 | 1 | 7.37 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406796 | — | — | 2 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406796 | — | EC50 | = | 42.69 | nM | 7.37 |
| CHEMBL5406796 | — | Activity | - | — | - |