Assay Detail
Functional
CHEMBL5345190
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Antimalarial activity against Plasmodium falciparum K1 assessed as reduction in parasitic growth incubated for 48 hrs by Giemsa-staining counting based microscopic analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent developments in antimalarial activities of 4-aminoquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.75 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 9.00 |
| CHEMBL5414694 | — | — | 1 | 7.70 |
| CHEMBL5408115 | — | — | 1 | 6.60 |
| CHEMBL5401139 | — | — | 1 | 6.52 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.48 |
| CHEMBL5424041 | — | — | 1 | 5.79 |
| CHEMBL5414795 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5414694 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5408115 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5401139 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5424041 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5414795 | — | EC50 | = | 7120.0 | nM | 5.15 |