Assay Detail
Functional
CHEMBL5345209
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Antimalarial activity against Chloroquine resistant Plasmodium falciparum RKL-9 assessed as parasitic growth inhibition measured after 36 hrs by Giemsa staining based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent developments in antimalarial activities of 4-aminoquinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.60 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777661 | — | — | 1 | 8.53 |
| CHEMBL5272909 | — | — | 1 | 7.80 |
| CHEMBL5274287 | — | — | 1 | 7.12 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777661 | — | IC50 | = | 2.94 | nM | 8.53 |
| CHEMBL5272909 | — | IC50 | = | 16.01 | nM | 7.80 |
| CHEMBL5274287 | — | IC50 | = | 75.01 | nM | 7.12 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 114.4 | nM | 6.94 |