Assay Detail
Functional
CHEMBL5345253
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CellTiter Aqueous One Solution MTS assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Flexibility in the bridge of chalcone derivatives is important for the inhibition of cellular growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.98 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105496 | 4-METHOXY CHALCONE | — | 1 | 5.28 |
| CHEMBL4083820 | — | — | 1 | 5.27 |
| CHEMBL2234233 | 4-FLUORO CHALCONE | — | 1 | 5.07 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.91 |
| CHEMBL375905 | — | — | 1 | 4.78 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | 4.58 |
| CHEMBL28689 | — | — | 1 | - |
| CHEMBL1965529 | — | — | 1 | - |
| CHEMBL28755 | — | — | 1 | - |
| CHEMBL29733 | — | — | 1 | - |
| CHEMBL281870 | — | — | 1 | - |
| CHEMBL5426093 | — | — | 1 | - |
| CHEMBL28591 | — | — | 1 | - |
| CHEMBL4160838 | — | — | 1 | - |
| CHEMBL30098 | — | — | 1 | - |
| CHEMBL28190 | — | — | 1 | - |
| CHEMBL30145 | — | — | 1 | - |
| CHEMBL4076747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105496 | 4-METHOXY CHALCONE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4083820 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL2234233 | 4-FLUORO CHALCONE | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL7976 | CHALCONE | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL375905 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL28689 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1965529 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL28755 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL29733 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL281870 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5426093 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL28591 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4160838 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL30098 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL28190 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL30145 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4076747 | — | IC50 | > | 30000.0 | nM | - |