Assay Detail
Functional
CHEMBL5345338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 5-(Pyrimidin-2-ylamino)-1<i>H</i>-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.30 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413288 | — | — | 1 | 6.40 |
| CHEMBL5395615 | — | — | 1 | 6.04 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.97 |
| CHEMBL5397722 | — | — | 1 | 5.77 |
| CHEMBL5417967 | — | — | 1 | 5.59 |
| CHEMBL5398492 | — | — | 1 | 5.51 |
| CHEMBL5429251 | — | — | 1 | 5.51 |
| CHEMBL5405845 | — | — | 1 | 5.49 |
| CHEMBL5410273 | — | — | 1 | 5.40 |
| CHEMBL5400123 | — | — | 1 | 5.37 |
| CHEMBL5439529 | — | — | 1 | 5.32 |
| CHEMBL5420265 | — | — | 1 | 5.27 |
| CHEMBL5399476 | — | — | 1 | 5.22 |
| CHEMBL5405669 | — | — | 1 | 5.21 |
| CHEMBL5419151 | — | — | 1 | 5.19 |
| CHEMBL5402174 | — | — | 1 | 5.17 |
| CHEMBL5398125 | — | — | 1 | 5.14 |
| CHEMBL5421297 | — | — | 1 | 5.11 |
| CHEMBL5417271 | — | — | 1 | 5.09 |
| CHEMBL5439561 | — | — | 1 | 5.08 |
| CHEMBL5412820 | — | — | 1 | 5.05 |
| CHEMBL5396391 | — | — | 1 | 4.99 |
| CHEMBL5267590 | — | — | 1 | 4.98 |
| CHEMBL5439920 | — | — | 1 | 4.95 |
| CHEMBL5408933 | — | — | 1 | 4.76 |
| CHEMBL5408694 | — | — | 1 | 4.76 |
| CHEMBL5417032 | — | — | 1 | 4.74 |
| CHEMBL5435190 | — | — | 1 | - |
| CHEMBL5416017 | — | — | 1 | - |
| CHEMBL5435931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413288 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5395615 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL301982 | CELASTROL | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5397722 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5417967 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5398492 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL5429251 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL5405845 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL5410273 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL5400123 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5439529 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL5420265 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL5399476 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL5405669 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL5419151 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL5402174 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5398125 | — | IC50 | = | 7240.0 | nM | 5.14 |
| CHEMBL5421297 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5417271 | — | IC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL5439561 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL5412820 | — | IC50 | = | 8870.0 | nM | 5.05 |
| CHEMBL5396391 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL5267590 | — | IC50 | = | 10540.0 | nM | 4.98 |
| CHEMBL5439920 | — | IC50 | = | 11140.0 | nM | 4.95 |
| CHEMBL5408933 | — | IC50 | = | 17420.0 | nM | 4.76 |
| CHEMBL5408694 | — | IC50 | = | 17260.0 | nM | 4.76 |
| CHEMBL5417032 | — | IC50 | = | 18240.0 | nM | 4.74 |
| CHEMBL5406475 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5425223 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5410579 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5439115 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5438016 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5397841 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5435931 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5416017 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5435190 | — | IC50 | > | 20000.0 | nM | - |