Assay Detail
Toxicity
CHEMBL5345339
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 5-(Pyrimidin-2-ylamino)-1<i>H</i>-indole-2-carboxamide Derivatives as Nur77 Modulators with Selective and Potent Activity Against Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.15 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420265 | — | — | 1 | 5.75 |
| CHEMBL5395615 | — | — | 1 | 5.68 |
| CHEMBL5396391 | — | — | 1 | 5.67 |
| CHEMBL5435190 | — | — | 1 | 5.54 |
| CHEMBL5399476 | — | — | 1 | 5.45 |
| CHEMBL5397722 | — | — | 1 | 5.41 |
| CHEMBL5439920 | — | — | 1 | 5.39 |
| CHEMBL5421297 | — | — | 1 | 5.30 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.26 |
| CHEMBL5402174 | — | — | 1 | 5.26 |
| CHEMBL5400123 | — | — | 1 | 5.19 |
| CHEMBL5419151 | — | — | 1 | 5.18 |
| CHEMBL5405669 | — | — | 1 | 5.13 |
| CHEMBL5410273 | — | — | 1 | 5.01 |
| CHEMBL5398125 | — | — | 1 | 4.89 |
| CHEMBL5405845 | — | — | 1 | 4.84 |
| CHEMBL5417967 | — | — | 1 | 4.83 |
| CHEMBL5438016 | — | — | 1 | 4.82 |
| CHEMBL5410579 | — | — | 1 | 4.81 |
| CHEMBL5425223 | — | — | 1 | 4.80 |
| CHEMBL5406475 | — | — | 1 | 4.72 |
| CHEMBL5413288 | — | — | 1 | 4.32 |
| CHEMBL5439561 | — | — | 1 | - |
| CHEMBL5416017 | — | — | 1 | - |
| CHEMBL5398492 | — | — | 1 | - |
| CHEMBL5439115 | — | — | 1 | - |
| CHEMBL5408933 | — | — | 1 | - |
| CHEMBL5435931 | — | — | 1 | - |
| CHEMBL5439529 | — | — | 1 | - |
| CHEMBL5267590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420265 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL5395615 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5396391 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5435190 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL5399476 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL5397722 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5439920 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL5421297 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL301982 | CELASTROL | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL5402174 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL5400123 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL5419151 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL5405669 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL5410273 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL5398125 | — | IC50 | = | 12960.0 | nM | 4.89 |
| CHEMBL5405845 | — | IC50 | = | 14280.0 | nM | 4.84 |
| CHEMBL5417967 | — | IC50 | = | 14960.0 | nM | 4.83 |
| CHEMBL5438016 | — | IC50 | = | 14990.0 | nM | 4.82 |
| CHEMBL5410579 | — | IC50 | = | 15410.0 | nM | 4.81 |
| CHEMBL5425223 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL5406475 | — | IC50 | = | 19170.0 | nM | 4.72 |
| CHEMBL5413288 | — | IC50 | = | 48010.0 | nM | 4.32 |
| CHEMBL5408694 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5412820 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5417271 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5397841 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5429251 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5417032 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5267590 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5439529 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5435931 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5408933 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5439115 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5398492 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5416017 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5439561 | — | IC50 | > | 20000.0 | nM | - |