Assay Detail
Functional
CHEMBL5345446
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Antiparasitic activity against Schistosoma mansoni assessed as effect on schistosomula phenotype incubated for 72 hrs by high content imaging analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Schistosoma mansoni |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small Molecule Ligands of the BET-like Bromodomain, <i>Sm</i>BRD3, Affect <i>Schistosoma mansoni</i> Survival, Oviposition, and Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.69 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407959 | — | — | 1 | 5.96 |
| CHEMBL5425680 | — | — | 1 | 5.96 |
| CHEMBL5401651 | — | — | 1 | 5.67 |
| CHEMBL5399078 | — | — | 1 | 5.67 |
| CHEMBL5427701 | — | — | 1 | 5.61 |
| CHEMBL5418728 | — | — | 1 | 5.61 |
| CHEMBL5439643 | — | — | 1 | 5.53 |
| CHEMBL5431587 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407959 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5425680 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5401651 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL5399078 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL5427701 | — | EC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL5418728 | — | EC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL5439643 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5431587 | — | EC50 | = | 2970.0 | nM | 5.53 |